Tay A A, Tseng C K, Pace N L, Wong K C, Hong-Goka B C
Can Anaesth Soc J. 1982 May;29(3):231-5. doi: 10.1007/BF03007122.
Sixteen dogs were used to study the analgesic effects of electroacupuncture. Electroacupuncture lowered halothane MAC significantly (1.21 +/- 0.04 to 1.05 +/- 0.05 per cent, p less than 0.005). Reversibility of this effect by narcotic antagonist was then studied, using naltrexone 5 mg . kg-1 injected intravenously (10 dogs) or 0.5 mg . kg-1 intrathecally (3 dogs). We failed to see any reversal of the effect of electroacupuncture on MAC. Narcotic antagonist reversibility of acupuncture effect is taken currently to imply endorphin mediation. Possible explanation for our result include an electroacupuncture analgesia not mediated by endorphins.
使用16只狗来研究电针的镇痛效果。电针显著降低了氟烷的最低肺泡有效浓度（从1.21±0.04%降至1.05±0.05%，p<0.005）。然后研究了麻醉拮抗剂对这种效应的可逆性，静脉注射5mg·kg-1纳曲酮（10只狗）或鞘内注射0.5mg·kg-1纳曲酮（3只狗）。我们未能观察到电针对最低肺泡有效浓度的效应有任何逆转。目前认为针刺效应的麻醉拮抗剂可逆性意味着内啡肽介导。对我们结果的可能解释包括电针镇痛不是由内啡肽介导的。
