有多少雾化吸入的布地奈德能到达婴幼儿体内？
How much nebulised budesonide reaches infants and toddlers?
作者信息
Lødrup Carlsen K C, Nikander K, Carlsen K H
机构信息
Paediatric Department, Ullevål Hospital, Oslo, Norway.
出版信息
Arch Dis Child. 1992 Sep;67(9):1077-9. doi: 10.1136/adc.67.9.1077.
The amount of budesonide suspension actually delivered to six subjects (aged 4-30 months) by a jet nebuliser and spacer system (System 22) was determined. Two nebulisations were performed in each subject using a filter at the exhalation outlet of the inhalation chamber. An inhalation filter was additionally attached between the facemask and the spacer in the first test. The drug was inhaled during the second test. The nebuliser equipment was washed with ethanol and the amount of drug deposited was determined. The amount of budesonide deposited in the exhalation filter increased when the inhalation filter was omitted. Only 14% of the nominal dose (500 micrograms) of budesonide was found in the inhalation filter, increasing from nine to 19% with increasing age. Approximately 75% of the nominal dose was found in the nebuliser equipment. These findings must be considered when deciding the nominal dose of budesonide suspension to be given to infants and toddlers.
测定了喷射雾化器和间隔器系统（22系统）实际输送给6名4至30个月大受试者的布地奈德混悬液量。在每个受试者中使用吸入室呼气出口处的过滤器进行两次雾化。在第一次测试中，在面罩和间隔器之间额外连接了一个吸入过滤器。在第二次测试中吸入药物。用乙醇清洗雾化器设备并测定沉积的药物量。省略吸入过滤器时，呼气过滤器中沉积的布地奈德量增加。在吸入过滤器中仅发现布地奈德标称剂量（500微克）的14%，随着年龄增长从9%增加到19%。在雾化器设备中发现约75%的标称剂量。在确定给予婴幼儿的布地奈德混悬液标称剂量时，必须考虑这些发现。
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