雾化布地奈德混悬液治疗重度依赖类固醇的学龄前哮喘
Treatment of severe steroid dependent preschool asthma with nebulised budesonide suspension.
作者信息
Ilangovan P, Pedersen S, Godfrey S, Nikander K, Noviski N, Warner J O
机构信息
Royal Brompton, National Heart and Lung Hospital, London.
出版信息
Arch Dis Child. 1993 Mar;68(3):356-9. doi: 10.1136/adc.68.3.356.
Abstract
The steroid sparing effect of nebulised budesonide suspension was assessed in a double blind placebo controlled parallel group study of 36 preschool children with severe asthma who were dependent on treatment with oral steroids. Nebulised budesonide suspension significantly reduced the requirement for treatment with oral steroids, and produced a marked improvement in overall health as scored on a visual analogue scale during the clinic visits. This study shows a significant step forward in the prophylactic treatment of asthma in children under the age of 3 years, in whom the efficacy of many other nebulised treatments has been questioned.
摘要
在一项双盲、安慰剂对照的平行组研究中，对36名依赖口服类固醇治疗的重度哮喘学龄前儿童评估了雾化布地奈德混悬液的类固醇节省效应。雾化布地奈德混悬液显著降低了口服类固醇的治疗需求，并在门诊就诊时通过视觉模拟量表评分显示整体健康状况有显著改善。这项研究表明，在3岁以下儿童哮喘的预防性治疗方面向前迈出了重要一步，而许多其他雾化治疗在这一年龄段儿童中的疗效一直受到质疑。
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本文引用的文献
1
Possible association between beclomethasone diproprionate aerosol and cataracts.
Aust Paediatr J. 1980 Jun;16(2):117-8. doi: 10.1111/j.1440-1754.1980.tb01276.x.
2
Short-term double-blind evaluation of flunisolide aerosol for steroid-dependent asthmatic children and adolescents.
Chest. 1981 Dec;80(6):671-5. doi: 10.1378/chest.80.6.671.
3
Nebulised ipratropium bromide and sodium cromoglycate in the first two years of life.
Arch Dis Child. 1984 Jan;59(1):54-7. doi: 10.1136/adc.59.1.54.
4
Assessment of the child with asthma.
J Asthma Res. 1970 Sep;8(1):31-6. doi: 10.3109/02770907009105028.
5
Jet-nebulized beclomethasone dipropionate in the management of bronchial asthma. Topical steroids for asthmatic children younger than 4 years.
Allergy. 1987 May;42(4):272-5. doi: 10.1111/j.1398-9995.1987.tb02209.x.
6
Nebulised beclomethasone dipropionate in preschool asthma.
Arch Dis Child. 1986 Mar;61(3):270-3. doi: 10.1136/adc.61.3.270.
7
Paradoxical response to nebulised salbutamol in wheezy infants, assessed by partial expiratory flow-volume curves.
Thorax. 1987 Feb;42(2):86-91. doi: 10.1136/thx.42.2.86.
8
Growth and childhood asthma.
Arch Dis Child. 1986 Nov;61(11):1049-55. doi: 10.1136/adc.61.11.1049.
9
Nebulised beclomethasone dipropionate in recurrent obstructive episodes after acute bronchiolitis.
Arch Dis Child. 1988 Dec;63(12):1428-33. doi: 10.1136/adc.63.12.1428.
10
Nebulised budesonide in severe infantile asthma.
Lancet. 1987 Oct 10;2(8563):851-2. doi: 10.1016/s0140-6736(87)91033-6.
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