Hirata H, Ogawa N, Haba K, Asanuma M, Chou H, Mori A
Department of Neuroscience, Okayama University Medical School, Japan.
Arch Int Pharmacodyn Ther. 1992 Jan-Feb;315:5-15.
Cerebral monoaminergic neurotransmitters and their metabolites show various concentration changes in gerbils following bilateral carotid ligation. The present study evaluated the effect of chronic administrations of lisuride hydrogen maleate (lisuride) on these changes. Lisuride (0.01 mg/kg or 0.05 mg/kg) or vehicle was intraperitoneally administered to gerbils for 14 consecutive days before the induction of a 30 min ischemia by bilateral carotid ligation. Animals were sacrified immediately and the levels of dopamine, DOPAC, homovanillic acid, noradrenaline, serotonin and 5-hydroxyindoleacetic acid determined by HPLC in the striatum, cortex, hippocampus and diencephalon/midbrain. Lisuride itself had no effect on any compound determined in any region. In the carotid-ligated gerbil brain, however, lisuride corrected the reduction of dopamine in the striatum, normalized or reduced increases in the (DOPAC+homovanillic acid)/dopamine ratio in the striatum, hippocampus and diencephalon/midbrain, and increased the levels of serotonin in all four regions. The present study, together with previous reports, indicate that lisuride may interfere with ischemia-induced cerebrovascular disturbances and, in such a way, improve some pathological sequelae of cerebrovascular disease.
双侧颈动脉结扎后，沙土鼠脑内单胺能神经递质及其代谢产物呈现出各种浓度变化。本研究评估了长期给予马来酸麦角乙脲（麦角乙脲）对这些变化的影响。在通过双侧颈动脉结扎诱导30分钟缺血前，连续14天给沙土鼠腹腔注射麦角乙脲（0.01mg/kg或0.05mg/kg）或赋形剂。动物立即处死，通过高效液相色谱法测定纹状体、皮质、海马和间脑/中脑中多巴胺、3,4-二羟基苯乙酸、高香草酸、去甲肾上腺素、5-羟色胺和5-羟吲哚乙酸的水平。麦角乙脲本身对任何区域测定的任何化合物均无影响。然而，在颈动脉结扎的沙土鼠脑中，麦角乙脲纠正了纹状体中多巴胺的减少，使纹状体、海马和间脑/中脑的（3,4-二羟基苯乙酸+高香草酸）/多巴胺比值的升高正常化或降低，并提高了所有四个区域中5-羟色胺的水平。本研究与先前的报告一起表明，麦角乙脲可能会干扰缺血诱导的脑血管紊乱，并以这种方式改善脑血管疾病的一些病理后遗症。
