Ogawa N, Haba K, Asanuma M, Kawata M, Mori A
Department of Neurochemistry, Okayama University Medical School, Japan.
Arch Int Pharmacodyn Ther. 1990 Nov-Dec;308:21-31.
Changes in various neurotransmitter systems of the gerbil brain during ischemia and the effects of administration of mergocryptine, a new ergot derivative, were studied. Gerbils intraperitoneally administered 0.5 mg/kg of mergocryptine or the vehicle once a day for 14 days were used. The administration of mergocryptine to control animals had no effect on the contents of neurotransmitters or their metabolites in various regions of the brain, but it corrected abnormalities in the neurotransmitter systems caused by ischemia. These results suggest the usefulness of mergocryptine against the deleterious effects of brain ischemia.
研究了沙鼠大脑在缺血期间各种神经递质系统的变化以及新型麦角衍生物麦角隐亭给药的影响。使用每天腹腔注射0.5mg/kg麦角隐亭或赋形剂，持续14天的沙鼠。对对照动物给予麦角隐亭对大脑各区域神经递质及其代谢物的含量没有影响，但它纠正了由缺血引起的神经递质系统异常。这些结果表明麦角隐亭对脑缺血的有害影响有用。
