Araki H, Uchiyama-Tsuyuki Y, Karasawa Y, Aihara H
Department of Pharmacology, Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Jpn J Pharmacol. 1989 Aug;50(4):445-53. doi: 10.1254/jjp.50.445.
Effects of minaprine, a psychotropic drug, on changes in monoamines and their metabolites were examined in Mongolian gerbils with 5-min occlusion of the common carotid arteries. Noradrenaline (NA), dopamine, serotonin (5-HT), 5-hydroxyindol acetic acid, homovanillic acid and 3,4-dihydroxyphenyl acetic acid contents in the cortex, hippocampus and striatum remained unaltered during a 5-min occlusion. NA levels in the cortex, hippocampus and striatum and 5-HT levels in the hippocampus and striatum significantly decreased 30 min-2 hr after re-circulation. Particularly, minaprine significantly inhibited the decrease of 5-HT in the hippocampus. These observations suggest that the effect of this drug on delayed neuronal death in the CA1 neurons in the hippocampus in Mongolian gerbils with occluded common carotid arteries may be related to the serotonergic system.
在蒙古沙鼠中，通过对颈总动脉进行5分钟的闭塞，研究了精神药物米那普明对单胺及其代谢产物变化的影响。在5分钟的闭塞期间，皮质、海马和纹状体中的去甲肾上腺素（NA）、多巴胺、5-羟色胺（5-HT）、5-羟吲哚乙酸、高香草酸和3,4-二羟基苯乙酸含量保持不变。再灌注后30分钟至2小时，皮质、海马和纹状体中的NA水平以及海马和纹状体中的5-HT水平显著降低。特别是，米那普明显著抑制了海马中5-HT的降低。这些观察结果表明，该药物对颈总动脉闭塞的蒙古沙鼠海马CA1神经元延迟性神经元死亡的影响可能与5-羟色胺能系统有关。
