在耐受与攻击的十字路口：重新审视“分层免疫系统”假说。
At the crossroads between tolerance and aggression: Revisiting the "layered immune system" hypothesis.
作者信息
Mold Jeff E, McCune Joseph M
机构信息
Department of Cell and Molecular Biology; Karolinska Institute; Stockholm, Sweden.
出版信息
Chimerism. 2011 Apr;2(2):35-41. doi: 10.4161/chim.2.2.16329.
Abstract
"We do not grow absolutely, chronologically. We grow sometimes in one dimension, and not in another; unevenly. We grow partially. We are relative. We are mature in one realm, childish in another. The past, present and future mingle and pull us backward, forward, or fix us in the present. We are made up of layers, cells, constellations."-Anaïs NinIt has long been recognized that the developing immune system exhibits certain peculiarities when compared to the adult immune system. Nonetheless, many still regard the fetal immune system as simply being an immature version of the adult immune system. Here we discuss historical evidence as well as recent findings, which suggest that the human immune system may develop in distinct layers with specific functions at different stages of development.
摘要
“我们并非按照时间顺序绝对地成长。我们有时在一个维度成长，而在另一个维度却没有；成长并不均衡。我们只是部分地成长。我们是相对的。我们在一个领域成熟，在另一个领域幼稚。过去、现在和未来相互交织，将我们拉回过去、推向未来，或者将我们定格在当下。我们由层层、细胞、星座组成。”——阿娜伊斯·宁
长期以来，人们已经认识到，与成人免疫系统相比，发育中的免疫系统表现出某些特殊性。然而，许多人仍然认为胎儿免疫系统仅仅是成人免疫系统的不成熟版本。在此，我们将讨论历史证据以及最近的研究发现，这些证据和发现表明，人类免疫系统可能在不同的发育阶段以具有特定功能的不同层次进行发育。
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