Cueto R, Squadrito G L, Bermudez E, Pryor W A
Biodynamics Institute, Louisiana State University, Baton Rouge 70803-1800.
Biochem Biophys Res Commun. 1992 Oct 15;188(1):129-34. doi: 10.1016/0006-291x(92)92359-6.
Heptanal and nonanal are identified from in vitro studies as potential biomarkers of exposure to ozone, the former resulting from ozonation of palmitoleic acid and the latter from oleic acid. An analytical method is developed based on derivatization using O-pentafluorobenzylhydroxylamine HCl and gas chromatography. These molecules also are present in the lung lavage of Sprague-Dawley rats exposed to 1.3 ppm ozone for 10 hr. These results suggest aldehydes may be useful dosimeters for ozone and indicate that unsaturated fatty acids in the lung lining fluid layer undergo ozonation in vivo.
在体外研究中，已鉴定出庚醛和壬醛是接触臭氧的潜在生物标志物，前者由棕榈油酸的臭氧化产生，后者由油酸产生。基于使用盐酸O-五氟苄基羟胺的衍生化和气相色谱法开发了一种分析方法。这些分子也存在于暴露于1.3 ppm臭氧10小时的Sprague-Dawley大鼠的肺灌洗液中。这些结果表明醛类可能是有用的臭氧剂量计，并表明肺衬液层中的不饱和脂肪酸在体内会发生臭氧化。
