氧化剂、抗氧化剂与呼吸道衬液
Oxidants, antioxidants, and respiratory tract lining fluids.
作者信息
Cross C E, van der Vliet A, O'Neill C A, Louie S, Halliwell B
机构信息
University of California-Davis Medical Center, Sacramento 95817.
出版信息
Environ Health Perspect. 1994 Dec;102 Suppl 10(Suppl 10):185-91. doi: 10.1289/ehp.94102s10185.
Abstract
Respiratory tract lining fluids (RTLFs) are a heterogeneous group of substances covering the respiratory tract epithelial cells (RTECs) from nasal mucosa to alveoli. Antioxidant contained in the RTLFs can be expected to provide an initial defense against inhaled environmental toxins. The major antioxidants in RTLF include mucin, uric acid, protein (largely albumin), ascorbic acid, and reduced glutathione (GSH). RTLF antioxidants can be augmented by such processes as transudation/exudation of plasma constituents; RTEC secretory processes, including glandular mucus secretion; and cellular antioxidants derived from lysis of RTECs and of inflammatory cells. The antioxidant composition of RTLFs and their role in modulating normal and pathophysiologic RTEC functions under conditions of oxidative stress are yet to be fully characterized.
摘要
呼吸道衬液（RTLFs）是一组异质性物质，覆盖从鼻粘膜到肺泡的呼吸道上皮细胞（RTECs）。预计RTLFs中含有的抗氧化剂可对吸入的环境毒素提供初始防御。RTLFs中的主要抗氧化剂包括粘蛋白、尿酸、蛋白质（主要是白蛋白）、抗坏血酸和还原型谷胱甘肽（GSH）。血浆成分的渗出/漏出等过程可增强RTLFs抗氧化剂；RTEC分泌过程，包括腺体粘液分泌；以及源自RTECs和炎症细胞裂解的细胞抗氧化剂。RTLFs的抗氧化剂组成及其在氧化应激条件下调节正常和病理生理RTEC功能中的作用尚未完全明确。
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