Shanmugam V, Nagarajan B
Department of Microbiology, Cancer Institute Madras, India.
Biochem Int. 1992 Aug;27(4):641-9.
The changes in sialoglycoconjugates synthesis after administration of 14C-glucose to fibrosarcoma bearing rats were studied. After 1 hr treatment 14C-glucose tumor bearing rat synthesized hexosamine which contained more radioactivity when compared to sialic acid. On fractionation of lipoproteins, low density lipoproteins (LDL) contained more sialic acid. This was further confirmed by separating the lipoproteins, as more radioactivity incorporation was observed in the LDL fraction. It is noteworthy that inspite of the tumor, high density lipoproteins (HDL) did not show any change.
研究了给荷纤维肉瘤大鼠注射14C-葡萄糖后唾液糖缀合物合成的变化。处理1小时后，荷瘤大鼠合成的己糖胺比唾液酸含有更多的放射性。在脂蛋白分级分离时，低密度脂蛋白（LDL）含有更多的唾液酸。通过分离脂蛋白进一步证实了这一点，因为在LDL组分中观察到更多的放射性掺入。值得注意的是，尽管存在肿瘤，高密度脂蛋白（HDL）并未显示出任何变化。
