基于重多肽链差异的人γ-2球蛋白亚类
SUBCLASSES OF HUMAN GAMMA-2-GLOBULIN BASED ON DIFFERENCES IN THE HEAVY POLYPEPTIDE CHAINS.
作者信息
TERRY W D, FAHEY J L
出版信息
Science. 1964 Oct 16;146(3642):400-1. doi: 10.1126/science.146.3642.400.
PMID:14186462
Abstract
Three subclasses of human gamma(2)-globulin (IgG) molecules were detected in normal human serum with antiserums prepared in monkeys. These subclasses, designated gamma(2a)-, gamma(2b)-, and gamma(2c)-globulins, have antibody activity. The distinguishing antigenic characteristics of each subclass were associated with the heavy polypeptide chains and the F (fast) fragments resulting from treatment of gamma(2)-globulins with papain.
摘要
用在猴子体内制备的抗血清在正常人血清中检测到了人类γ(2)-球蛋白（IgG）分子的三个亚类。这些亚类，分别命名为γ(2a)-、γ(2b)-和γ(2c)-球蛋白，具有抗体活性。每个亚类独特的抗原特性与重多肽链以及用木瓜蛋白酶处理γ(2)-球蛋白后产生的F（快速）片段有关。
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