Sharma H M, Geer J C
Am J Pathol. 1977 Aug;88(2):255-66.
The mechanisms by which serum sickness cause lesions in the aortic intima are not known. The early aortic lesions of serum sickness detected by permeability to Evans blue dye were studied morphologically to determine the chronologic sequence of lesion initiation and immunochemically with fluorescein-labeled rabbit IgG and bovine serum albumin to detect the presence of antigen and antibody. The topographic localization of lesions and the morphologic changes observed suggest that endothelial injury occurs first, probably due to immune complex deposition, and that platelets play a secondary or reactive role in the process.
血清病导致主动脉内膜损伤的机制尚不清楚。通过伊文思蓝染料通透性检测到的血清病早期主动脉损伤进行了形态学研究,以确定损伤起始的时间顺序,并使用荧光素标记的兔IgG和牛血清白蛋白进行免疫化学检测,以检测抗原和抗体的存在。损伤的局部定位和观察到的形态学变化表明,内皮损伤首先发生,可能是由于免疫复合物沉积,并且血小板在该过程中起次要或反应性作用。