Vicens A, Iriarte J, de Castro P, Castejón C, Martínez-Lage J M
Departamento de Neurología, Clínica Universitaria de Navarra, Pamplona.
Neurologia. 1992 Aug-Sep;7(7):171-5.
Although the presence of intellectual impairment in multiple sclerosis (MS) is known since the first studies of the disease frequently the impairment goes equally undetected for the patients, their family and the physician because the physical dysfunction is much more outstanding. In this study a population of 50 persons suffering clinically definite MS (Poser's criteria) and 50 healthy controls matched with the patients in sex, age and cultural level were submitted to a neuropsychological test battery (NPTB). The existence of a correlation between the punctuation obtained in the NPTB and factors such as the level of disability, the time of evolution, the type of MS and the work status was searched. The results show a greater difficulty in doing tasks requiring attention-concentration skills thus giving the MS patients significantly lower scores in the memory test when compared with the controls. The execution of all tests was worse in those forms of MS with the longest time of evolution, higher EDSS scores and the chronic-progressive types. In our study the loss of the working status was never due to the intellectual impairment, it was because of the physical disability.
尽管自对多发性硬化症（MS）的首批研究以来，就已知道该病存在智力障碍，但由于身体功能障碍更为突出，患者及其家人和医生常常同样未能察觉这种障碍。在本研究中，对50名临床确诊为MS（波泽标准）的患者以及50名在性别、年龄和文化水平上与患者匹配的健康对照者进行了一套神经心理测试（NPTB）。研究了NPTB中所得分数与残疾程度、病程、MS类型和工作状态等因素之间的相关性。结果显示，在完成需要注意力集中技能的任务时，MS患者存在更大困难，因此与对照组相比，他们在记忆测试中的得分明显更低。在病程最长、扩展残疾状态量表（EDSS）得分更高以及慢性进展型的MS类型中，所有测试的执行情况更差。在我们的研究中，工作状态的丧失从未归因于智力障碍，而是由于身体残疾。
