Silvestrini R, Valentinis B, Daidone M G, Di Fronzo G, Coradini D, Salvadori B
Oncologia Chirurgica C, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.
Eur J Cancer. 1992;28A(12):2006-10. doi: 10.1016/0959-8049(92)90249-2.
Proliferative activity, evaluated as [3H]thymidine labelling index ([3H]dT LI), and hormone receptors were determined on 97 primary breast cancers and on metachronous lesions from the same patient. Overall, the [3H]dT LI of metachronous lesions was significantly higher than that of the primary tumour (P = 0.003). Hormone receptor profiles of the two lesions were similar in about 75% of the cases; disagreements were mainly due to a disappearance of hormone receptors in metachronous lesions. In contralateral tumours, [3H]dT LI and hormone receptors were unrelated to those of the relative primary lesion. In this series of relapsing patients, [3H]dT LI was unrelated to hormone receptor status in the primary tumour, but it was higher in the metachronous lesions from patients with hormone receptor-negative primary tumours. For patients given no systemic therapy between surgery and relapse, the time to develop local-regional recurrences or contralateral tumours was inversely related to the [3H]dT LI of the metachronous lesions.
通过[3H]胸腺嘧啶核苷标记指数（[3H]dT LI）评估增殖活性，并对97例原发性乳腺癌及同一患者的异时性病变进行激素受体检测。总体而言，异时性病变的[3H]dT LI显著高于原发性肿瘤（P = 0.003）。在约75%的病例中，两种病变的激素受体谱相似；不一致主要是由于异时性病变中激素受体消失。在对侧肿瘤中，[3H]dT LI和激素受体与相对应的原发性病变无关。在这组复发患者中，[3H]dT LI与原发性肿瘤的激素受体状态无关，但在激素受体阴性原发性肿瘤患者的异时性病变中更高。对于手术与复发之间未接受全身治疗的患者，发生局部区域复发或对侧肿瘤的时间与异时性病变的[3H]dT LI呈负相关。
