右利手和左利手精神分裂症患者及对照受试者自身抗体的患病率。

The prevalence of autoantibodies among right and left handed schizophrenic patients and control subjects.

作者信息

Chengappa K N, Ganguli R, Ulrich R, Rabin B S, Cochran J, Brar J S, Yang Z W, Deleo M

机构信息

Department of Psychiatry (Immunopsychiatry Program), Western Psychiatric Institute & Clinic, University of Pittsburgh, School of Medicine, PA 15213-2593.

出版信息

Biol Psychiatry. 1992 Nov 1;32(9):803-11. doi: 10.1016/0006-3223(92)90083-c.

DOI:10.1016/0006-3223(92)90083-c

PMID:1450294

Abstract

Sera from schizophrenic patients (n = 186) and healthy control subjects (n = 346) were tested for the presence of seven common autoantibodies by standard immunological methods. The association between handedness and autoantibodies was tested in a multi-way contingency table using a log-linear model. For men, but not women, nondextrals (patients and controls) were twice as likely to test positive for autoantibodies than dextrals (p = 0.0002). Although more women (33%) than men (24%) tested positive for autoantibodies, handedness was not a distinguishing factor among women. These data suggest that sinistrality and gender are associated with autoantibodies in a subgroup of schizophrenic patients and healthy control subjects.

摘要

采用标准免疫学方法，对186例精神分裂症患者和346例健康对照者的血清进行了7种常见自身抗体检测。使用对数线性模型在多向列联表中检验利手与自身抗体之间的关联。对于男性而非女性，非右利手者（患者和对照）检测自身抗体呈阳性的可能性是右利手者的两倍（p = 0.0002）。尽管检测自身抗体呈阳性的女性（33%）多于男性（24%），但利手并非女性中的一个区分因素。这些数据表明，在精神分裂症患者和健康对照者的一个亚组中，左利手和性别与自身抗体有关。