Courtney M A, Bader A M, Hartwell B, Hauch M, Grennan M J, Datta S
Brigham and Women's Hospital, Boston, MA 02115.
Reg Anesth. 1992 Sep-Oct;17(5):274-8.
Thirty-seven ASA Physical Status I parturients undergoing elective cesarean delivery were evaluated to determine the effects of subarachnoid sufentanil administration.
This study was carried out in a randomized, double-blind fashion. All patients received 1.4 ml 0.75% bupivacaine with 8.25% dextrose following 10 micrograms, 15 micrograms, or 20 micrograms sufentanil, or 1 ml of normal saline containing no sufentanil. Onset and duration of sensory and motor anesthesia, duration of complete analgesia, duration of effective analgesia, and intraoperative parenteral opioid requirements were evaluated. Incidence of side effects such as respiratory depression, pruritus, nausea, and vomiting were evaluated.
Duration of complete analgesia and duration of effective analgesia were prolonged significantly in all patient groups receiving sufentanil as compared to control groups receiving no narcotic. Pruritus was significantly increased in patient groups receiving subarachnoid sufentanil. Respiratory depression was not observed in any patient studied. One- and five-minute Apgar scores; umbilical, venous, and arterial blood gas results; and Early Neonatal Neurobehavioral Scale results were all within normal limits and were not significantly different among the groups.
对37例接受择期剖宫产的美国麻醉医师协会（ASA）身体状况I级产妇进行评估，以确定蛛网膜下腔注射舒芬太尼的效果。
本研究采用随机、双盲方式进行。所有患者在接受10微克、15微克或20微克舒芬太尼，或1毫升不含舒芬太尼的生理盐水后，接受1.4毫升含8.25%葡萄糖的0.75%布比卡因。评估感觉和运动麻醉的起效时间和持续时间、完全镇痛的持续时间、有效镇痛的持续时间以及术中肠外阿片类药物的需求量。评估呼吸抑制、瘙痒、恶心和呕吐等副作用的发生率。
与未接受麻醉的对照组相比，所有接受舒芬太尼的患者组的完全镇痛持续时间和有效镇痛持续时间均显著延长。接受蛛网膜下腔舒芬太尼的患者组瘙痒明显增加。在所有研究患者中均未观察到呼吸抑制。1分钟和5分钟阿氏评分、脐血、静脉血和动脉血气结果以及早期新生儿神经行为量表结果均在正常范围内，且各组之间无显著差异。
