Wysocki A B
J ET Nurs. 1992 Sep-Oct;19(5):166-70.
Fibronectin, a fibrillar glycoprotein, is the major adhesive protein deposited at the wound interface during acute wound healing. Its abilities to interact with both cells and matrix are responsible for its description and characterization as a multifunctional adhesive glycoprotein. Fibronectin functions to promote cell adhesion, cell shape and spreading, organization of the cytoskeleton, hemostasis and thrombosis, cell migration, and phagocytosis. Both in vitro and in vivo studies indicate that fibronectin interacts with cells important to wound healing, including platelets, neutrophils, monocytes, fibroblasts, endothelial cells, and epidermal cells. It promotes adhesion between cells and between cell and matrix, cell spreading, migration, chemotaxis, phagocytosis, and matrix and basement membrane organization. Fibronectin is consequently active during each stage of wound healing. Its importance in acute wound healing is now widely recognized. More recently, investigators have begun to study fibronectin's role in chronic wounds. This article briefly reviews fibronectin, outlines its role in wound healing, and discusses current research on fibronectin in chronic wounds.
纤连蛋白是一种纤维状糖蛋白，是急性伤口愈合过程中沉积在伤口界面的主要黏附蛋白。它与细胞和基质相互作用的能力使其被描述和表征为一种多功能黏附糖蛋白。纤连蛋白的功能包括促进细胞黏附、细胞形态和铺展、细胞骨架组织、止血和血栓形成、细胞迁移以及吞噬作用。体外和体内研究均表明，纤连蛋白与对伤口愈合至关重要的细胞相互作用，包括血小板、中性粒细胞、单核细胞、成纤维细胞、内皮细胞和表皮细胞。它促进细胞之间以及细胞与基质之间的黏附、细胞铺展、迁移、趋化性、吞噬作用以及基质和基底膜组织。因此，纤连蛋白在伤口愈合的各个阶段均发挥作用。其在急性伤口愈合中的重要性现已得到广泛认可。最近，研究人员已开始研究纤连蛋白在慢性伤口中的作用。本文简要介绍纤连蛋白，概述其在伤口愈合中的作用，并讨论目前关于纤连蛋白在慢性伤口中的研究。
