Clark R A
Dermatology Program, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Arch Dermatol. 1988 Feb;124(2):201-6.
Fibronectin has many potential roles in wound repair, including chemotactic factor activity for monocytes, fibroblasts, and endothelial cells; opsonin activity and opsonin promoter activity for microorganism and tissue debris; substratum for cell migration and localization; and a scaffold for building extracellular matrix. Although fibronectin has been reported to have intrinsic growth-promoting ability, coisolation of authentic growth factors with fibronectin raises doubts about this observation. Whether the addition of exogenous fibronectin to wounds can augment healing is a question for future studies.
纤连蛋白在伤口修复中具有许多潜在作用，包括对单核细胞、成纤维细胞和内皮细胞的趋化因子活性；对微生物和组织碎片的调理素活性及调理素启动子活性；细胞迁移和定位的基质；以及构建细胞外基质的支架。尽管有报道称纤连蛋白具有内在的促生长能力，但纤连蛋白与真正的生长因子共同分离这一现象对此观察结果提出了质疑。向伤口添加外源性纤连蛋白是否能促进愈合是未来研究的一个问题。
