Grinnell F
J Cell Biochem. 1984;26(2):107-16. doi: 10.1002/jcb.240260206.
I have tried to briefly review the evidence (summarized in Table II) indicating that fibronectin is important in cutaneous wound healing. Fibronectin appears to be an important factor throughout this process. It promotes the spreading of platelets at the site of injury, the adhesion and migration of neutrophils, monocytes, fibroblasts, and endothelial cells into the wound region, and the migration of epidermal cells through the granulation tissue. At the level of matrix synthesis, fibronectin appears to be involved both in the organization of the granulation tissue and basement membrane. In terms of tissue remodeling, fibronectin functions as a nonimmune opsonin for phagocytosis of debris by fibroblasts, keratinocytes, and under some circumstances, macrophages. Fibronectin also enhances the phagocytosis of immune-opsonized particles by monocytes, but whether this includes phagocytosis of bacteria remains to be determined. In general, phagocytosis of bacteria has not appeared to involve fibronectin. On the contrary, the presence of fibronectin in the wound bed may promote bacterial attachment and infection. Because of the ease of experimental manipulations, wound healing experiments have been carried out on skin more frequently than other tissues. As a result, the possible role of fibronectin has not been investigated thoroughly in the repair of internal organs and tissues. Nevertheless, it seems reasonable to speculate that fibronectin plays a central role in all wound healing situations. Finally, the wound healing problems of patients with severe factor XIII deficiencies may occur because of their inability to incorporate fibronectin into blood clots.
我已尝试简要回顾（总结于表二）表明纤连蛋白在皮肤伤口愈合中起重要作用的证据。在整个过程中，纤连蛋白似乎都是一个重要因素。它促进血小板在损伤部位的铺展，促进中性粒细胞、单核细胞、成纤维细胞和内皮细胞黏附并迁移至伤口区域，以及促进表皮细胞穿过肉芽组织迁移。在基质合成层面，纤连蛋白似乎参与肉芽组织和基底膜的形成。在组织重塑方面，纤连蛋白作为一种非免疫调理素，促进成纤维细胞、角质形成细胞，以及在某些情况下巨噬细胞对碎片的吞噬作用。纤连蛋白还增强单核细胞对免疫调理颗粒的吞噬作用，但这是否包括对细菌的吞噬作用仍有待确定。一般来说，细菌的吞噬作用似乎不涉及纤连蛋白。相反，伤口床中纤连蛋白的存在可能会促进细菌黏附和感染。由于实验操作简便，与其他组织相比，在皮肤上进行伤口愈合实验更为频繁。因此，纤连蛋白在内部器官和组织修复中的可能作用尚未得到充分研究。然而，推测纤连蛋白在所有伤口愈合情况中都起核心作用似乎是合理的。最后，严重因子 XIII 缺乏症患者的伤口愈合问题可能是由于他们无法将纤连蛋白整合到血凝块中。
