Rittmannsberger H, Leblhuber F
Department of Psychiatry, Wagner-Jauregg-Krankenhaus, Linz, Austria.
Biol Psychiatry. 1992 Aug 15;32(4):364-8. doi: 10.1016/0006-3223(92)90040-7.
There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents. In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage. Neither dosage nor serum levels of CBZ were in a higher range. We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.
关于扑翼样震颤作为精神药物治疗副作用的报道非常少。在本报告中，我们介绍了4例接受不同精神药物联合治疗的患者，他们的扑翼样震颤要么是在治疗方案中加用卡马西平（CBZ）时引发的，要么是在增加其剂量时引发的。CBZ的剂量和血清水平均未处于较高范围。我们认为扑翼样震颤是一种容易被忽视的神经毒性体征，即使在低剂量或中等剂量水平，如果锂盐或氯氮平之类的某些药物与CBZ联合使用，也可能会出现。
