Bartlett J G
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Clin Infect Dis. 1992 Oct;15(4):573-81. doi: 10.1093/clind/15.4.573.
Diarrhea is clearly one of the most common side effects encountered with antimicrobial treatment. Virtually all drugs with an antibacterial spectrum of activity have been implicated, although there are definite differences in associated incidence rates that appear to depend on spectrum of activity and pharmacokinetic properties. Most cases of antibiotic-associated diarrhea can be classified in two categories: cases in which Clostridium difficile is implicated and cases in which no putative agent or recognized pathophysiological mechanism is clearly established. This review is intended to provide management guidelines for patients with diarrhea that occurs in association with antibacterial agents.
腹泻显然是抗菌治疗中最常见的副作用之一。几乎所有具有抗菌活性谱的药物都与之相关，尽管在相关发病率上存在明显差异，这似乎取决于活性谱和药代动力学特性。大多数抗生素相关性腹泻病例可分为两类：与艰难梭菌有关的病例和未明确确定假定病原体或公认病理生理机制的病例。本综述旨在为与抗菌药物相关的腹泻患者提供管理指南。
