AKR小鼠白血病前期晚期鼠白血病病毒抗原表达的变化及嗜异性病毒的产生
Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice.
作者信息
Kawashima K, Ikeda H, Hartley J W, Stockert E, Rowe W P, Old L J
出版信息
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4680-4. doi: 10.1073/pnas.73.12.4680.
Abstract
We recently reported that thymocytes from 6-month-old preleukemic AKR mice express higher levels of murine leukemia virus (MuLV)-related antigens that thymocytes from 2-month-old mice. We have now found that the level of xenotropic MuLV (defined operationally as MuLV able to infect mink cell cultures) is also markedly increased in thymus of 6-month-old AKR mice and that this increase in virus correlates closely with increased MuLV-antigen expression. There is no increase of MuLV antigen or xenotropic virus in spleen or lymph nodes. Production of ecotropic MuLV remains unchanged with age in thymus, lymph nodes, and spleen. Thymic grafts from 6-month-old AKR mice, but not from 2-month-old mice, induce both amplified MuLV-antigen expression and xenotropic virus production in the thymus of young AKR recipients. Experiments with lethally irradiated AKR mice reconstituted with syngeneic bone marrow cells indicate that age-related changes in the thymus rather than in bone marrow precursor cells are responsible for MuLV-antigen amplification.
摘要
我们最近报道，6月龄白血病前期AKR小鼠的胸腺细胞表达的鼠白血病病毒（MuLV）相关抗原水平高于2月龄小鼠的胸腺细胞。我们现在发现，嗜异性MuLV（在操作上定义为能够感染貂细胞培养物的MuLV）水平在6月龄AKR小鼠的胸腺中也显著升高，并且这种病毒的增加与MuLV抗原表达的增加密切相关。脾脏或淋巴结中MuLV抗原或嗜异性病毒没有增加。胸腺、淋巴结和脾脏中亲嗜性MuLV的产生随年龄保持不变。6月龄AKR小鼠的胸腺移植，但2月龄小鼠的胸腺移植不会，在年轻AKR受体的胸腺中诱导MuLV抗原表达扩增和嗜异性病毒产生。用同基因骨髓细胞重建的经致死性照射的AKR小鼠实验表明，胸腺中与年龄相关的变化而非骨髓前体细胞的变化是MuLV抗原扩增的原因。
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