Wang Hongyu, Zhang Wenjing, Sun Yun, Xu Xican, Chen Xiaoyang, Zhao Kexu, Yang Zhao, Liu Huiyu
State Key Laboratory of Organic-Inorganic Composites, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 100029, Beijing, China.
State Key Laboratory of Green Biomanufacturing, Innovation Center of Molecular Diagnostics, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.
Bioact Mater. 2025 Apr 3;50:61-94. doi: 10.1016/j.bioactmat.2025.03.016. eCollection 2025 Aug.
Cancer stem cells (CSCs) represent a distinct subpopulation of cancer cells that orchestrate cancer initiation, progression, metastasis, and therapeutic resistance. Despite advances in conventional therapies, the persistence of CSCs remains a major obstacle to achieving cancer eradication. Nanomedicine-based approaches have emerged for precise CSC targeting and elimination, offering unique advantages in overcoming the limitations of traditional treatments. This review systematically analyzes recent developments in nanomedicine for CSC-targeted therapy, emphasizing innovative nanomaterial designs addressing CSC-specific challenges. We first provide a detailed examination of CSC biology, focusing on their surface markers, signaling networks, microenvironmental interactions, and metabolic signatures. On this basis, we critically evaluate cutting-edge nanomaterial engineering designed to exploit these CSC traits, including stimuli-responsive nanodrugs, nanocarriers for drug delivery, and multifunctional nanoplatforms capable of generating localized hyperthermia or reactive oxygen species. These sophisticated nanotherapeutic approaches enhance selectivity and efficacy in CSC elimination, potentially circumventing drug resistance and cancer recurrence. Finally, we present an in-depth analysis of current challenges in translating nanomedicine-based CSC-targeted therapies from bench to bedside, offering critical insights into future research directions and clinical implementation. This review aims to provide a comprehensive framework for understanding the intersection of nanomedicine and CSC biology, contributing to more effective cancer treatment modalities.
癌症干细胞（CSCs）是癌细胞中的一个独特亚群，它们在癌症的起始、进展、转移和治疗耐药性中起着关键作用。尽管传统疗法取得了进展，但癌症干细胞的持续存在仍然是实现癌症根除的主要障碍。基于纳米医学的方法已出现用于精确靶向和消除癌症干细胞，在克服传统治疗的局限性方面具有独特优势。本综述系统地分析了用于癌症干细胞靶向治疗的纳米医学的最新进展，强调了解决癌症干细胞特异性挑战的创新纳米材料设计。我们首先详细研究了癌症干细胞生物学，重点关注其表面标志物、信号网络、微环境相互作用和代谢特征。在此基础上，我们批判性地评估了旨在利用这些癌症干细胞特性的前沿纳米材料工程，包括刺激响应性纳米药物、药物递送纳米载体以及能够产生局部热疗或活性氧的多功能纳米平台。这些先进的纳米治疗方法提高了消除癌症干细胞的选择性和疗效，有可能规避耐药性和癌症复发。最后，我们深入分析了将基于纳米医学的癌症干细胞靶向治疗从实验室转化到临床应用目前面临的挑战，为未来的研究方向和临床实施提供了关键见解。本综述旨在提供一个全面的框架，以理解纳米医学与癌症干细胞生物学的交叉点，为更有效的癌症治疗模式做出贡献。
Zotero 插件
