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白血病前期AKR胸腺细胞表面抗原的年龄相关变化。

Age-related changes in cell surface antigens of preleukemic AKR thymocytes.

作者信息

Kawashima K, Ikeda H, Stockert E, Takahashi T, Old L J

出版信息

J Exp Med. 1976 Jul 1;144(1):193-208. doi: 10.1084/jem.144.1.193.

DOI:10.1084/jem.144.1.193
PMID:180229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2190365/
Abstract

Thymocytes from preleukemic AKR mice aged 5-6 mo have an altered pattern of cell surface antigens. The expression of four MuLV-related antigens on the cell surface (GIX, GCSA, gp70, p30) is markedly increased in comparison to 2-mo-old AKR mice and approximates the heightened levels of these antigens found on thymic leukemia cells. H-2 and Thy-1 alloantigens also show characteristic modifications in relation to age and leukemia development. In contrast to the high Thy-1/low H-2 levels on 2-mo-old AKR thymocytes, thymocytes from 6-mo-old mice and thymic leukemia cells frequently show a low Thy-1/high H-2 surface phenotype. As thymocytes from mouse strains with a low incidence of leukemia do not show these changes, they appear to represent a stage in the conversion of normal cells to leukemia cells.

摘要

5至6月龄的白血病前期AKR小鼠的胸腺细胞具有改变的细胞表面抗原模式。与2月龄的AKR小鼠相比，细胞表面四种与小鼠白血病病毒（MuLV）相关的抗原（GIX、GCSA、gp70、p30）的表达显著增加，接近在胸腺白血病细胞上发现的这些抗原的升高水平。H-2和Thy-1同种异体抗原也显示出与年龄和白血病发展相关的特征性改变。与2月龄AKR胸腺细胞上高Thy-1/低H-2水平相反，6月龄小鼠的胸腺细胞和胸腺白血病细胞经常显示出低Thy-1/高H-2表面表型。由于白血病发病率低的小鼠品系的胸腺细胞没有显示出这些变化，它们似乎代表了正常细胞向白血病细胞转化的一个阶段。

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Age-related changes in cell surface antigens of preleukemic AKR thymocytes.白血病前期AKR胸腺细胞表面抗原的年龄相关变化。
J Exp Med. 1976 Jul 1;144(1):193-208. doi: 10.1084/jem.144.1.193.
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Immunologic, virologic, and genetic aspects of mammary tumor virus-induced cell-surface antigens: presence of these antigens and the Thy 1.2 antigen on murine mammary gland and tumor cells.乳腺肿瘤病毒诱导的细胞表面抗原的免疫学、病毒学和遗传学方面：这些抗原及Thy 1.2抗原在小鼠乳腺和肿瘤细胞上的存在情况。
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Thymic epithelium controls thymocyte expression of preleukemic phenotype and leukemogenic retroviruses.胸腺上皮细胞控制胸腺细胞白血病前期表型和致白血病逆转录病毒的表达。
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Cancer Immun. 2012;12:2. Epub 2012 May 1.
2
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts.马萨诸塞州波士顿塔夫茨大学医学院内科
Immunogenetics. 1981;14(1-2):169-76. doi: 10.1007/BF00344310.
3
Potential leukemic cells among bone marrow cells of young AKR/J mice.年轻AKR/J小鼠骨髓细胞中的潜在白血病细胞。
Proc Natl Acad Sci U S A. 1980 May;77(5):2923-6. doi: 10.1073/pnas.77.5.2923.
4
Thymic epithelial genotype influences the production of recombinant leukemogenic retroviruses in mice.胸腺上皮基因型影响小鼠重组白血病逆转录病毒的产生。
J Virol. 1983 Jul;47(1):33-45. doi: 10.1128/JVI.47.1.33-45.1983.
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J Virol. 1983 Feb;45(2):755-65. doi: 10.1128/JVI.45.2.755-765.1983.
6
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J Virol. 1982 Aug;43(2):416-26. doi: 10.1128/JVI.43.2.416-426.1982.
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本文引用的文献

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"Spontaneous" leukemia developing in C3H mice following inoculation in infancy, with AK-leukemic extracts, or AK-embrvos.在婴儿期接种AK白血病提取物或AK胚胎后，C3H小鼠中发生的“自发性”白血病。
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GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKAEMOGENESIS.病毒致白血病易感性的遗传基础。
Lancet. 1964 Dec 5;2(7371):1207-9. doi: 10.1016/s0140-6736(64)91043-8.
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THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.AKR胸腺抗原及其在白血病和神经组织中的分布。
J Exp Med. 1964 Sep 1;120(3):413-33. doi: 10.1084/jem.120.3.413.
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UNILATERAL HISTOGENESIS OF AKR THYMIC LYMPHOMA.Akr胸腺淋巴瘤的单侧组织发生
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The thymus and lymph-nodes in radiation chimaeras.辐射嵌合体中的胸腺和淋巴结。
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Conditioned and autonomous neoplasms: a review.条件性和自主性肿瘤：综述
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Occurrence of natural antibody to the G (gross) leukemia antigen in mice.小鼠中针对G（总）白血病抗原的天然抗体的出现。
Cancer Res. 1966 Jul;26(7):1415-9.
8
Isoantigens of the H-2 and Tla loci of the mouse: interactions affecting their representation on thymocytes.小鼠H-2和Tla位点的同种抗原：影响其在胸腺细胞上表达的相互作用。
J Exp Med. 1968 Jul 1;128(1):85-95. doi: 10.1084/jem.128.1.85.
9
The G-IX system. A cell surface allo-antigen associated with murine leukemia virus; implications regarding chromosomal integration of the viral genome.G-IX系统。一种与鼠白血病病毒相关的细胞表面同种异体抗原；关于病毒基因组染色体整合的意义。
J Exp Med. 1971 Jun 1;133(6):1334-55. doi: 10.1084/jem.133.6.1334.
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G (Gross) and H-2 cell-surface antigens: location on Gross leukemia cells by electron microscopy with visually labeled antibody.G（总）和H-2细胞表面抗原：通过电子显微镜和视觉标记抗体确定其在格罗斯白血病细胞上的定位。
Proc Natl Acad Sci U S A. 1970 Mar;65(3):569-76. doi: 10.1073/pnas.65.3.569.