• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

放线菌素D：对大鼠肝脏匀浆的作用与其对RNA合成的作用无关。

ACTINOMYCIN D: AN EFFECT ON RAT LIVER HOMOGENATES UNRELATED TO ITS ACTION ON RNA SYNTHESIS.

作者信息

REVEL M, HIATT H H, REVEL J P

出版信息

Science. 1964 Dec 4;146(3649):1311-3. doi: 10.1126/science.146.3649.1311.

DOI:10.1126/science.146.3649.1311
PMID:14207459
Abstract

Liver homogenates prepared from rats injected with high doses of actinomycin D show a decrease in polyribosome content and in amino acid incorporation. These effects are not observed in rat liver not subjected to homogenization and are independent of the inhibition of RNA synthesis caused by the antibiotic.

摘要

用高剂量放线菌素D注射的大鼠制备的肝匀浆显示多核糖体含量和氨基酸掺入量减少。在未进行匀浆处理的大鼠肝脏中未观察到这些效应，并且这些效应与抗生素引起的RNA合成抑制无关。

相似文献

1
ACTINOMYCIN D: AN EFFECT ON RAT LIVER HOMOGENATES UNRELATED TO ITS ACTION ON RNA SYNTHESIS.放线菌素D：对大鼠肝脏匀浆的作用与其对RNA合成的作用无关。
Science. 1964 Dec 4;146(3649):1311-3. doi: 10.1126/science.146.3649.1311.
2
STUDIES ON THE MECHANISM OF METHYLCHOLANTHRENE INDUCTION OF ENZYME ACTIVITIES. II. STIMULATION OF MICROSOMAL AND RIBOSOMAL AMINO ACID INCORPORATION: THE EFFECTS OF POLYURIDYLIC ACID AND ACTINOMYCIN-D.甲基胆蒽诱导酶活性的机制研究。II. 对微粒体和核糖体氨基酸掺入的刺激作用：多聚尿苷酸和放线菌素-D的影响。
Biochim Biophys Acta. 1964 Sep 11;91:130-44.
3
[PERSISTENCE OF D-RNA SYNTHESIS IN THE LIVER OF RATS TREATED WITH ACTINOMYCIN].[放线菌素处理大鼠肝脏中D-RNA合成的持续性]
Biochim Biophys Acta. 1964 Jun 22;87:212-8.
4
MESSENGER RIBONUCLEIC ACID OF RAT LIVER CYTOPLASM.大鼠肝脏细胞质信使核糖核酸
Nature. 1964 Mar 21;201:1194-7. doi: 10.1038/2011194a0.
5
ACTINOMYCIN D AND MESSENGER-RNA TURNOVER.放线菌素D与信使核糖核酸周转
Nature. 1964 Sep 12;203:1134-6. doi: 10.1038/2031134a0.
6
ACTINOMYCIN D. EFFECTS ON NUCLEIC ACID AND PROTEIN METABOLISM IN INTACT AND REGENERATING LIVER OF RATS.放线菌素D。对大鼠完整肝脏和再生肝脏中核酸与蛋白质代谢的影响。
Cancer Res. 1965 Apr;25:307-17.
7
A RAPID METHOD FOR PREPARING GRANULAR AND AGRANULAR ENDOPLASMIC RETICULUM AND FREE RIBOSOMES FROM RAT LIVER.一种从大鼠肝脏制备颗粒型和无颗粒型内质网及游离核糖体的快速方法。
Q J Exp Physiol Cogn Med Sci. 1965 Jan;50:93-103. doi: 10.1113/expphysiol.1965.sp001774.
8
[PROPERTIES OF A D-RNA SYNTHESIZED IN VIVO IN THE PRESENCE OF ACTINOMYCIN IN THE RAT LIVER].[在放线菌素存在的情况下大鼠肝脏中体内合成的一种D-RNA的特性]
J Physiol (Paris). 1964 May-Jun;56:298-9.
9
Protein synthesis in rat liver: influence of amino acids in diet on microsomes and polysomes.大鼠肝脏中的蛋白质合成：饮食中的氨基酸对微粒体和多核糖体的影响。
Science. 1965 Oct 29;150(3696):628-9. doi: 10.1126/science.150.3696.628.
10
[BIOSYNTHESIS OF RIBOSOME RNA IN THE NUCLEOLUS (NUCLEONEMAL APPARATUS OF THE CELL)].[核仁（细胞的核丝装置）中核糖体RNA的生物合成]
Biokhimiia. 1964 May-Jun;29:518-28.

引用本文的文献

1
Studies on Phytoalexins: The Relationship between Actinomycin D and Ribonucleic Acid Synthesis during the Induction of Phaseollin in the French Bean (Phaseolus vulgaris L.).植物抗毒素的研究：链丝菌素 D 与诱导菜豆（Phaseolus vulgaris L.）产生 Phaseollin 过程中 RNA 合成的关系。
Plant Physiol. 1972 Dec;50(6):660-6. doi: 10.1104/pp.50.6.660.
2
Evidence for an Inactivating System of Nitrate Reductase in Hordeum vulgare L. during Darkness That Requires Protein Synthesis.大麦中存在一种在黑暗中使硝酸还原酶失活的系统的证据，该系统需要蛋白质合成。
Plant Physiol. 1969 Aug;44(8):1150-6. doi: 10.1104/pp.44.8.1150.
3
Evidence for in vivo Light-induced Synthesis of Ribulose-1,5-diP Carboxylase and Phosphoribulokinase in Greening Barley Leaves.
活体中光诱导的核酮糖-1,5-二磷酸羧化酶和磷酸核酮糖激酶的合成证据。
Plant Physiol. 1967 Sep;42(9):1277-83. doi: 10.1104/pp.42.9.1277.
4
Inhibition by actinomycin D of uridine diphosphoglucose synthetase activity during differentiation of Dictyostelium discoideum.放线菌素D对盘基网柄菌分化过程中尿苷二磷酸葡萄糖合成酶活性的抑制作用。
J Bacteriol. 1967 Jun;93(6):1762-4. doi: 10.1128/jb.93.6.1762-1764.1967.
5
Histological studies on the effect of actinomycin D on retrograde nerve cell reaction in the facial nucleus of mice.放线菌素D对小鼠面神经核逆行性神经细胞反应影响的组织学研究。
Acta Neuropathol. 1967 Oct 20;9(2):146-57. doi: 10.1007/BF00691440.
6
The effect of feeding with a tryptophan-free amino acid mixture on rat-liver polysomes and ribosomal ribonucleic acid.用无色氨酸氨基酸混合物喂养对大鼠肝脏多核糖体和核糖体核糖核酸的影响。
Biochem J. 1966 Nov;101(2):417-28. doi: 10.1042/bj1010417.
7
Inhibition of inducible liver enzymes by endotoxin and actinomycin D.内毒素和放线菌素D对诱导性肝酶的抑制作用。
J Bacteriol. 1966 Jul;92(1):107-15. doi: 10.1128/jb.92.1.107-115.1966.
8
Studies on cells producing haemolytic antibodies against sheep red blood cells in short-term experiments in vitro.关于在体外短期实验中产生抗绵羊红细胞溶血抗体的细胞的研究。
Immunology. 1966 Jan;10(1):45-55.
9
Primary antibody response studied by using inhibitors of nucleic acid synthesis.利用核酸合成抑制剂研究初次抗体应答。
Folia Microbiol (Praha). 1966;11(2):102-11. doi: 10.1007/BF02878838.
10
Effect of actinomycin D on the induction of uterine alkaline phosphatase of growing rats by 17-beta-estradiol.放线菌素D对17-β-雌二醇诱导生长中大鼠子宫碱性磷酸酶的影响。
Experientia. 1968 Oct 15;24(10):1024. doi: 10.1007/BF02138724.