Mineshita S, Tian D, Wang L M, Jian X Y, Li S Y, Fang G Z, Bian T Y, Liao H S, Tsuchida M, Tanaka H
People's Hospital, Beijing Medical University (Xuanwu Hospital, Capital Institute of Medicine.
Intern Med. 1992 Sep;31(9):1073-5. doi: 10.2169/internalmedicine.31.1073.
Among Han nationality Chinese and living in the northern area of the Yellow River, 120 patients suffering from Behçet's disease and 100 unrelated healthy individuals were typed for histocompatibility antigens (HLA)-A, -B, -C, and -DR and -DQ antigens. HLA-DR and DQ typing was performed on B-lymphocyte separated with Lympho-B-Kwik. The HLA-antisera were provided by 11th IHWC. Bf alleles and C4 allotypes were determined by immunofixation agarose-gel electrophoresis. HLA-B51 was found in 67/120 (55.83%) patients and in 12/100 (12%) controls, the Chi-square and relative risk values were 45.54 and 9.27, respectively (p < 0.0005). C4AQ0 frequency was significantly increased in the patient group. In the complete form group HLA-B51 was observed more frequently (62.79%). No significant differences of other HLA antigens, frequencies, Bf or B4 alleles were found between the groups.
在居住于黄河以北地区的汉族人群中，对120例白塞病患者和100名无关健康个体进行了组织相容性抗原（HLA）-A、-B、-C以及-DR和-DQ抗原分型。采用Lympho-B-Kwik分离的B淋巴细胞进行HLA-DR和DQ分型。HLA抗血清由第11届国际组织相容性研讨会提供。通过免疫固定琼脂糖凝胶电泳测定Bf等位基因和C4同种异型。在120例患者中有67例（55.83%）发现HLA-B51，在100名对照中有12例（12%）发现，卡方值和相对风险值分别为45.54和9.27（p < 0.0005）。患者组中C4AQ0频率显著升高。在完全型组中HLA-B51的观察频率更高（62.79%）。两组之间在其他HLA抗原、频率、Bf或B4等位基因方面未发现显著差异。
