意大利人中与HLA - B51和DRw52抗原相关的白塞病。

Behcet's disease associated with HLA-B51 and DRw52 antigens in Italians.

作者信息

Baricordi O R, Sensi A, Pivetti-Pezzi P, Perrone S, Balboni A, Catarinelli G, Filippi F, Melchiorri L, Moncada A, Mattiuz P L

出版信息

Hum Immunol. 1986 Nov;17(3):297-301. doi: 10.1016/0198-8859(86)90281-8.

DOI:10.1016/0198-8859(86)90281-8

PMID:2432045

Abstract

Thirty-eight Italian patients with Behcet's disease, all with ocular involvement, (28 complete type and ten incomplete) were typed for HLA A,B,DR, and DQ antigens. A significant increase of HLA-B51 (p less than 0.00001) and DRw52 (p = 0.045) with no significant difference between complete and incomplete syndrome was found. The involvement of B51 antigen as the main immunogenetic factor in the disease is suggested by the high value of relative risk (RR = 16.03). However, the association with the II class antigen DRw52 (RR = 2.77) cannot be easily explained as a secondary association due to linkage disequilibria with B51.

摘要

38例患有白塞病且均有眼部受累的意大利患者（28例完全型和10例不完全型）进行了HLA A、B、DR和DQ抗原分型。结果发现HLA - B51（p<0.00001）和DRw52（p = 0.045）显著增加，完全型和不完全型综合征之间无显著差异。相对风险值较高（RR = 16.03）提示B51抗原作为该疾病主要免疫遗传因素的参与。然而，与II类抗原DRw52的关联（RR = 2.77）不能轻易解释为由于与B51的连锁不平衡导致的次要关联。