Kadomatsu K, Nakagawara A, Zaizen Y, Nagoshi M, Tsuneyoshi M, Fukushige T, Haigou A, Suita S
Department of Pediatric Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Surg Today. 1992;22(5):451-5. doi: 10.1007/BF00308797.
Undifferentiated (embryonal) sarcoma is a rare malignant tumor of the liver. It typically presents in late childhood and its prognosis is poor. We experienced three cases of such a tumor during the period of 1976-1989; two of these patients are still alive without disease. Each case was independently treated with a combination of surgery and pre- and/or postoperative chemotherapy, which was found to be effective. In one surviving patient, cyclophosphamide and vincristine were found to be effective, while in the other a combination of cisplatin, Adriamycin (ADM), vincristine and cyclophosphamide was observed to induce a rapid reduction in the size of the recurrent tumor. Thus, an adequate combination of surgery and chemotherapy may improve the prognosis of this tumor.
未分化（胚胎性）肉瘤是一种罕见的肝脏恶性肿瘤。它通常在儿童晚期出现，预后较差。在1976年至1989年期间，我们遇到了3例这种肿瘤；其中2例患者仍存活且无疾病。每例均独立接受了手术联合术前和/或术后化疗的治疗，发现这种治疗有效。在1例存活患者中，发现环磷酰胺和长春新碱有效，而在另一例中，观察到顺铂、阿霉素（ADM）、长春新碱和环磷酰胺联合使用可使复发性肿瘤迅速缩小。因此，手术和化疗的适当联合可能改善这种肿瘤的预后。
