Gunawardena S W, Trautwein L M, Finegold M J, Ogden A K
Texas Children's Hospital, Houston 77030, USA.
Med Pediatr Oncol. 1997 Feb;28(2):139-43. doi: 10.1002/(sici)1096-911x(199702)28:2<139::aid-mpo9>3.0.co;2-l.
We report a 3-year and 11-month-old Caucasian female, who initially presented with an unresectable hepatic angiosarcoma. After three courses of chemotherapy with adriamycin/cisplatin, the tumor decreased in size considerably, allowing complete surgical resection. She also received postoperative chemotherapy with alternating cycles of ifosfamide/etoposide, cisplatinum/adriamycin, and vincristine/actinomycin D/cyclophosphamide for 18 months. She remains disease-free for greater than 44 months from the initial diagnosis. Our experience suggests that total excision of the tumor, together with an aggressive chemotherapy regimen, can improve the disease-free survival for children with this highly malignant vascular tumor of the liver.
我们报告了一名3岁11个月大的白种女性，最初表现为不可切除的肝血管肉瘤。在接受了三个疗程的阿霉素/顺铂化疗后，肿瘤大小显著减小，从而得以进行完整的手术切除。她术后还接受了异环磷酰胺/依托泊苷、顺铂/阿霉素以及长春新碱/放线菌素D/环磷酰胺交替循环的化疗，为期18个月。自初次诊断以来，她已无病生存超过44个月。我们的经验表明，肿瘤的完全切除以及积极的化疗方案可提高患有这种高恶性肝脏血管肿瘤儿童的无病生存率。
