Ngan P K, Khanh N G, Tuong C V, Quy P P, Anh D N, Thuy H T
Institute for the Protection of Children's Health, Hanoi, Vietnam.
Acta Paediatr Suppl. 1992 Sep;381:124-6.
The clinical and laboratory features of persistent diarrhea were investigated in 83 children under three years of age who were treated in the Gastroenterology Division of the Institute for the Protection of Children's Health, Hanoi from August 1988 to August 1989. The number of cases of diarrhea was highest in the children aged 4-5 months. The mean age of the children studied was 6.6 +/- 3.4 months. The ratio of males to females was 2.6 and mean age of first episode of diarrhea was 4.3 +/- 3.4 months; persistent diarrhea was more common in children under six months of age than in older children. Persistent diarrhea occurred in the first diarrheal episode in 66.5% of cases. Recent nonenteric infections were found in 30% of the study group. Of the 83 children studied, 36% had stool specimens positive for enteric pathogens; 24% had enterotoxigenic Escherichia coli isolated, 8% had enteropathogenic E. coli, 5% rotavirus, 6% Candida, and 4% Giardia lamblia. The duration of diarrhea was longer in children who received antibiotics than in those who did not (p < 0.01).
1988年8月至1989年8月期间，对在河内儿童健康保护研究所胃肠病科接受治疗的83名三岁以下儿童的持续性腹泻的临床和实验室特征进行了调查。腹泻病例数在4至5个月大的儿童中最高。所研究儿童的平均年龄为6.6±3.4个月。男女比例为2.6，首次腹泻发作的平均年龄为4.3±3.4个月；持续性腹泻在六个月以下的儿童中比在年龄较大的儿童中更常见。66.5%的病例持续性腹泻发生在首次腹泻发作时。30%的研究组儿童近期有非肠道感染。在83名研究儿童中，36%的粪便标本肠道病原体呈阳性；24%分离出产肠毒素大肠杆菌，8%为致病性大肠杆菌，5%为轮状病毒，6%为念珠菌，4%为蓝氏贾第鞭毛虫。接受抗生素治疗的儿童腹泻持续时间比未接受抗生素治疗的儿童更长（p<0.01）。
