Girard A, Phan M L, Weise F, Elghozi J L
Laboratory of Pharmacology, CNRS URA 1482, Faculty of Medicine Necker-E.M., Paris, France.
Clin Auton Res. 1992 Oct;2(5):299-302. doi: 10.1007/BF01824299.
The acute effect of mild central hypovolaemia induced by plasmapheresis on the short-term variability of blood pressure and heart rate was evaluated in ten healthy donors. Indirect finger blood pressure was measured by a non-invasive device (Finapres). Analogue-to-digital conversion of the blood pressure was used to determine systolic, diastolic and mean blood pressure and heart rate every second. The equidistant sampling allowed a direct spectral analysis using a fast Fourier transform algorithm. Blood pressure and heart rate were maintained while an increased overall variability of blood pressure was observed after plasmapheresis. The increased total area under the curve of the systolic and diastolic blood pressure spectra was documented with the selective analysis of the three main components of the spectra: the increase in the oscillations of blood pressure following plasmapheresis predominated in the 66-129 mHz region, corresponding to Mayer waves. The spectral profile of HR was unaffected by plasmapheresis. The significant increase in the 10-s period oscillations of blood pressure after the mild central hypovolaemia could result from the unloading of cardiopulmonary (and arterial) baroreceptors which in turn could buffer the arterial pressure through sympathetic activation, detected on the systolic and diastolic pressure spectra in the low-frequency range.
在10名健康献血者中评估了血浆置换引起的轻度中枢性血容量不足对血压和心率短期变异性的急性影响。通过无创设备（Finapres）测量间接手指血压。血压的模数转换用于每秒确定收缩压、舒张压、平均血压和心率。等距采样允许使用快速傅里叶变换算法进行直接频谱分析。血浆置换后观察到血压总体变异性增加，而血压和心率保持稳定。通过对频谱的三个主要成分进行选择性分析，记录了收缩压和舒张压频谱曲线下总面积的增加：血浆置换后血压振荡的增加在66-129 mHz区域占主导，对应于迈尔波。心率的频谱特征不受血浆置换的影响。轻度中枢性血容量不足后血压10秒周期振荡的显著增加可能是由于心肺（和动脉）压力感受器卸载，这反过来又可以通过交感神经激活缓冲动脉压力，在低频范围内的收缩压和舒张压频谱中检测到。
