呼肠孤病毒血细胞凝集作用：N-乙酰-D-葡萄糖胺的抑制作用

REOVIRUS HEMAGGLUTINATION: INHIBITION BY N-ACETYL-D-GLUCOSAMINE.

作者信息

GELB L D, LERNER A M

出版信息

Science. 1965 Jan 22;147(3656):404-5. doi: 10.1126/science.147.3656.404.

DOI:10.1126/science.147.3656.404

Abstract

Purified reoviruses types 1, 2, and 3 were specifically inhibited in their hemagglutination of human erythrocytes by 250 micromoles or more of N-acetyl-D-glucosamine but not by over 20 other sugars tested. N-acetyl-D-glucosamine inhibited reovirus hemaglutination by binding to capsid virus; it did not attach to the erythrocytes. It is possible that reovirus hemagglutination involves union between N-acetyl-D-glucosamine on the surface of the red cell and the glycoprotein of the virus coat.

摘要

250微摩尔或更多的N-乙酰-D-葡萄糖胺可特异性抑制纯化的1型、2型和3型呼肠孤病毒对人红细胞的血凝作用，但对其他20多种测试糖类则无此作用。N-乙酰-D-葡萄糖胺通过与衣壳病毒结合来抑制呼肠孤病毒的血凝作用；它并不附着于红细胞。呼肠孤病毒的血凝作用可能涉及红细胞表面的N-乙酰-D-葡萄糖胺与病毒衣壳糖蛋白之间的结合。