一种凝集素样受体参与恶性疟原虫对红细胞的侵袭。
A lectin-like receptor is involved in invasion of erythrocytes by Plasmodium falciparum.
作者信息
Jungery M, Pasvol G, Newbold C I, Weatherall D J
出版信息
Proc Natl Acad Sci U S A. 1983 Feb;80(4):1018-22. doi: 10.1073/pnas.80.4.1018.
Abstract
Glycophorin both in solution and inserted into liposomes blocks invasion of erythrocytes by the malaria parasite Plasmodium falciparum. Furthermore, one sugar, N-acetyl-D-glucosamine (GlcNAc), completely blocks invasion of the erythrocyte by this parasite. GlcNAc coupled to bovine serum albumin to prevent the sugar entering infected erythrocytes was at least 100,000 times more effective than GlcNAc alone. Bovine serum albumin coupled to lactose or bovine serum albumin alone had no effect on invasion. These results suggest that the binding of P. falciparum to erythrocytes is lectin-like and is determined by carbohydrates on glycophorin.
摘要
无论是在溶液中还是插入脂质体中的血型糖蛋白，均可阻止疟原虫恶性疟原虫对红细胞的侵袭。此外，一种糖类物质，N-乙酰-D-葡萄糖胺（GlcNAc），能完全阻止该寄生虫对红细胞的侵袭。与牛血清白蛋白偶联以防止糖类进入受感染红细胞的GlcNAc，其效果比单独的GlcNAc至少强100,000倍。与乳糖偶联的牛血清白蛋白或单独的牛血清白蛋白对侵袭均无影响。这些结果表明，恶性疟原虫与红细胞的结合类似凝集素，且由血型糖蛋白上的碳水化合物决定。
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