Ladilov Iu V, Islamov B I, Vorob'ev S I
Eksp Klin Farmakol. 1992 Mar-Apr;55(2):23-5.
The anti-ischemic effect of a 4% proxanol solution (intravenous injection in a dose of 10 ml/kg 60 min after occlusion) was compared with that of a salt solution in experimental acute ischemia of dog myocardium, induced by partial occlusion of the anterior descending branch of the left coronary artery. Overall estimation of the effect of SAS infusion has demonstrated that this drug has a beneficial effect on hemorheology (decreases blood viscosity and vascular resistance, increases coronary blood flow), stabilizes oxygen supply of the myocardium and lowers the extent of its ischemia-induced damage (eliminates ST segment depression). However, the cardiodepressive action of proxanol does not allow for compensation of the ischemia-induced decrease in myocardial contractility and pump function of the heart.
在由左冠状动脉前降支部分闭塞诱导的犬心肌实验性急性缺血中，将4%普罗沙诺溶液（闭塞60分钟后以10毫升/千克的剂量静脉注射）的抗缺血作用与盐溶液的抗缺血作用进行了比较。对SAS输注效果的总体评估表明，该药物对血液流变学有有益作用（降低血液粘度和血管阻力，增加冠状动脉血流量），稳定心肌的氧气供应并降低其缺血性损伤的程度（消除ST段压低）。然而，普罗沙诺的心脏抑制作用无法代偿缺血引起的心肌收缩力下降和心脏泵功能下降。
