Ladilov Iu V, Islamov B I, Vorob'ev S I, Ivanitskiĭ G R
Biull Eksp Biol Med. 1991 Feb;111(2):139-42.
On the 60th minute after inducing the acute ischemia in the canine myocardium by the occlusion of the left anterior descending coronary artery, the animals were intravenously infused with perfluorochemical emulsion (PFCE), its salt composition (SC) or 4% surface-active substance (SAS), proxanol, at a dose of 10 ml/kg. Two hours after infusion, the occlusion was removed (reperfusion). The arterial pO2 was maintained at 120 mm Hg. Analysis of the blood flow, oxygen supply, acid-alkali balance, ECG, as well as creatine phosphokinase activity, measured in the ischemic area, has shown that PFC emulsion is capable of reducing ischemic damage and preventing reperfusion-induced myocardium injury. Thus, the presence of perfluorochemicals in the PFC emulsion is an essential factor in its ischemia-protective effect.
通过结扎左冠状动脉前降支诱导犬心肌急性缺血60分钟后，给动物静脉输注全氟化合物乳剂（PFCE）、其盐组合物（SC）或4%表面活性物质（SAS）普洛沙诺尔，剂量为10 ml/kg。输注两小时后，解除结扎（再灌注）。动脉血氧分压维持在120 mmHg。对缺血区域的血流、氧供应、酸碱平衡、心电图以及肌酸磷酸激酶活性进行分析，结果表明全氟化合物乳剂能够减轻缺血损伤并预防再灌注诱导的心肌损伤。因此，全氟化合物乳剂中全氟化合物的存在是其缺血保护作用的关键因素。
