Chichkanov G G, Tsorin I B, Kirsanova G Iu
Laboratory of Blood Circulation Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Eksp Klin Farmakol. 1998 Nov-Dec;61(6):20-4.
Experiments on narcotized cats demonstrated that the derivatives of 2-mercaptobenzimidazole possessing the properties of specific bradycardic agents and coded as CM-251, CM-266, and CM-345, reduce the mean rise of segment ST on numerous leads of the epicardial electrogram during 5-min occlusion of the anterior descending branch of the left coronary artery. The agents stabilize the heart pumping and contracting functions under conditions of 30- and 60-min reperfusion of the coronary artery, respectively. It is concluded on the grounds of the obtained data that the 2-mercaptobenzimidazole derivatives possess a marked anti-ischemic action.
对麻醉猫进行的实验表明，具有特定心动过缓作用且编码为CM - 251、CM - 266和CM - 345的2 - 巯基苯并咪唑衍生物，可降低左冠状动脉前降支闭塞5分钟内心外膜心电图多个导联上ST段的平均抬高幅度。这些药物分别在冠状动脉30分钟和60分钟再灌注的情况下稳定心脏的泵血和收缩功能。根据所获数据得出结论，2 - 巯基苯并咪唑衍生物具有显著的抗缺血作用。
