LEVINE S, WENK E J
Science. 1964 Dec 25;146(3652):1681-2. doi: 10.1126/science.146.3652.1681.
The hyperacute form of allergic encephalomyelitis is characterized by its short incubation period, 100 percent incidence, overwhelming severity, and high mortality and by the massive quantities of polymorphonuclear neutrophils, fibrin, and edema fluid which infiltrate the central nervous system. The hyperacute form has been produced with the aid of aqueous pertussis vaccine as an adjuvant. This is the first reproducible laboratory model for human acute necrotizing hemorrhagic encephalopathy.
过敏性脑脊髓炎的超急性形式的特点是潜伏期短、发病率100%、病情极其严重、死亡率高,以及大量多形核中性粒细胞、纤维蛋白和水肿液浸润中枢神经系统。超急性形式是借助水性百日咳疫苗作为佐剂产生的。这是人类急性坏死性出血性脑病的首个可重复的实验室模型。