Wardlaw A C, Parton R, Bergman R K, Munoz J J
Immunology. 1979 Jul;37(3):539-45.
The adjuvanticity of a phenotypic (C-mode) variant of B. pertussis, known to be deficient in certain immunological and physiopathological properties, was compared to that of the normal (X-mode) strain. The X-mode vaccine was a potent adjuvant for induction of hyperacute experimental allergic encephalomyelitis to guinea-pig spinal cord in Lewis rats whereas C-mode vaccine was inactive. X-mode vaccine was also highly active in the induction of reaginic (both IgE and IgGl) antibodies to ovalbumin in mice while C-mode vaccine caused only a transitory increase in the IgE level. These data support the view that an adjuvant component of B. pertussis, which is probably identical with the histamine-sensitizing and leukocytosis promoting factor, is much diminished in C-mode cells while the lipopolysaccharide adjuvant remains unchanged.
已知百日咳博德特氏菌的一种表型（C模式）变体在某些免疫和生理病理特性方面存在缺陷，将其佐剂性与正常（X模式）菌株进行了比较。X模式疫苗是诱导Lewis大鼠对豚鼠脊髓产生超急性实验性过敏性脑脊髓炎的有效佐剂，而C模式疫苗则无活性。X模式疫苗在诱导小鼠对卵清蛋白产生反应素（IgE和IgG1）抗体方面也具有高度活性，而C模式疫苗仅使IgE水平出现短暂升高。这些数据支持这样一种观点，即百日咳博德特氏菌的一种佐剂成分，可能与组胺致敏和促进白细胞增多因子相同，在C模式细胞中大大减少，而脂多糖佐剂保持不变。
