HIRSCHHORN R, KAPLAN J M, GOLDBERG A F, HIRSCHHORN K, WEISSMANN G
Science. 1965 Jan 1;147(3653):55-7. doi: 10.1126/science.147.3653.55.
Human lymphocytes, cultured in the presence of phytohemagglutinin, undergo morphologic transformation and subsequent mitosis. Before mitosis (48 to 72 hours), a sharp increase in acid phosphatase activity occurs in cells stimulated with phytohemagglutinin. Histochemical examination of these cells demonstrates that innumerable granules containing acid phosphatase develop in the cytoplasm before mitosis. It is possible that enzymes present in granules which stain for acid phosphatase activity (lysosome-like) may play a role in phytohemagglutinin-stimulated cell division.
在植物血凝素存在的情况下培养的人淋巴细胞会发生形态转化并随后进行有丝分裂。在有丝分裂前（48至72小时），用植物血凝素刺激的细胞中酸性磷酸酶活性会急剧增加。对这些细胞进行组织化学检查表明，在有丝分裂前细胞质中会形成无数含有酸性磷酸酶的颗粒。有可能存在于对酸性磷酸酶活性呈阳性染色的颗粒（类溶酶体）中的酶在植物血凝素刺激的细胞分裂中起作用。
