HIRSCHHORN K, BACH F, KOLODNY R L, FIRSCHEIN I L, HASHEM N
Science. 1963 Nov 29;142(3596):1185-7. doi: 10.1126/science.142.3596.1185.
Phytohemagglutinin causes cultured lymphocytes to agglutinate, divide, and produce gamma-globulin. Most cells are transformed into large lymphocytes, some resembling plasmocytes. Actinomycin D stops gamma-globulin production after 2 hours. When specific antigens are added to lymphocytes from sensitized individuals, only some cells undergo morphological transformation, produce gamma-globulin, and divide. When cells or cell extracts from an unrelated individual are added to a culture, a similar reaction occurs.
植物血凝素可使培养的淋巴细胞凝集、分裂并产生γ球蛋白。大多数细胞转化为大淋巴细胞，有些类似浆细胞。放线菌素D在2小时后可阻止γ球蛋白的产生。当将特定抗原添加到致敏个体的淋巴细胞中时，只有一些细胞会发生形态转化、产生γ球蛋白并分裂。当将来自无关个体的细胞或细胞提取物添加到培养物中时，会发生类似的反应。
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