Ziganshina L E, Studentsova I A, Ziganshin A U, Valeeva I Kh
Eksp Klin Farmakol. 1992 Mar-Apr;55(2):43-5.
It has been established in experiments on rats that the 7-day administration of dimephosphon per os increases blood levels of total mercapto groups and glutathione, changing the correlation of its forms in favour of the oxidized ones. This course of dimephosphon administration reduces blood concentration of lipid peroxidation products. The significance of these mechanisms in realization of the pharmacological effects of dimephosphon is under discussion.
在大鼠实验中已证实,经口给予二巯丙磺钠7天可提高血液中总巯基和谷胱甘肽的水平,改变其各形式之间的相关性,有利于氧化型。这种二巯丙磺钠给药过程可降低脂质过氧化产物的血液浓度。这些机制在二巯丙磺钠药理作用实现中的意义正在讨论中。