[二膦酸对腺嘌呤核苷酸系统的影响]
[Effect of dimephosphon on the adenine nucleotide system].
作者信息
Ziganshin A U, Studentsova I A, Zaikonnikova I V
出版信息
Farmakol Toksikol. 1988 Jul-Aug;51(4):80-2.
PMID:3191981
Abstract
The effect of a single injection of dimephosphon (1 mM/kg) on adenine nucleotide system in the liver of healthy and chlorophos-poisoned (a mean lethal dose) rats was studied. It was shown that in healthy rats dimephosphon decreased the levels of all components of adenylate system without changing the energy charge of adenylates. The treatment of the poisoned animals with dimephosphon normalized the parameters of energy metabolism disturbed by chlorophos intoxication.
摘要
研究了单次注射二磷膦（1 mM/kg）对健康大鼠及毒死蜱中毒（平均致死剂量）大鼠肝脏中腺嘌呤核苷酸系统的影响。结果表明，在健康大鼠中，二磷膦降低了腺苷酸系统所有组分的水平，但未改变腺苷酸的能荷。用二磷膦治疗中毒动物可使毒死蜱中毒所扰乱的能量代谢参数恢复正常。
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