Paxinos G, Burt J, Atrens D M, Jackson D M
Pharmacol Biochem Behav. 1977 Apr;6(4):439-47. doi: 10.1016/0091-3057(77)90182-4.
Forty-four male rats were tested for eating, drinking, irritability, and copulation before and after intraperitonial para-chlorophenylalanine (PCPA) or control injections. Eleven of these rats were tested for muricide before and after PCPA injections (Group 1), while 18 others were tested only after PCPA injections (Groups 2). Group 1 rats received four 350 mg/kg PCPA injections spaced 6 days apart and showed hyperdipsia, weight loss, and a 24% increase in muricide. Group 2 rats received five daily 100 mg/kg PCPA injections repeated 11 days later and showed hyperdipsia and weight loss; in addition, 78% of them killed mice. Neither group showed significant changes in copulation. At the end of the experiment, t6 rats from Group 2 that were irritable and killed mice were injected intraperitonially with 5-hydroxytryptophan (80 mg/kg). Five of these rats lost their irritability and four stopped killing. The various behavioral changes were not corrleated significantly either with each other or with the degree of 5-hydroxytryptamine depletion. This tentatively suggests that PCPA may produce its effects on behavior by other means in addition to 5-hydroxytryptamine depletion.
对44只雄性大鼠在腹腔注射对氯苯丙氨酸（PCPA）或对照注射前后进行进食、饮水、易怒性和交配测试。其中11只大鼠在PCPA注射前后进行杀鼠测试（第1组），另外18只仅在PCPA注射后进行测试（第2组）。第1组大鼠接受4次350mg/kg的PCPA注射，间隔6天，表现出多饮、体重减轻和杀鼠行为增加24%。第2组大鼠每天接受5次100mg/kg的PCPA注射，11天后重复注射，表现出多饮和体重减轻；此外，其中78%的大鼠杀死了小鼠。两组在交配方面均未表现出显著变化。实验结束时，对第2组中易怒且杀鼠的16只大鼠腹腔注射5-羟色氨酸（80mg/kg）。其中5只大鼠不再易怒，4只停止杀鼠。各种行为变化彼此之间或与5-羟色胺耗竭程度均无显著相关性。这初步表明，PCPA除了通过耗尽5-羟色胺外，可能还通过其他方式对行为产生影响。
