Ventura J, Nuechterlein K H, Hardesty J P, Gitlin M
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles 90024-6968.
Br J Psychiatry. 1992 Nov;161:615-20. doi: 10.1192/bjp.161.5.615.
Research with schizophrenic out-patients has shown that antipsychotic medication reduces relapse rates. This protective factor may operate partially by raising the threshold for relapse in the face of environmental stressors such as life events and high levels of familial expressed emotion. A prospective, longitudinal design was employed in the monthly collection of life-events data with 23 recent-onset schizophrenic out-patients. In a between-subjects ANOVA, a significantly higher frequency of independent life events was found in the month prior to a relapse for ten patients on medication, as compared with the analogous month for 13 drug-free patients. These findings suggest that neuroleptic medication may produce a prophylactic effect by raising a patient's threshold of vulnerability to relapse.
针对精神分裂症门诊患者的研究表明，抗精神病药物可降低复发率。这一保护因素可能部分是通过提高患者面对生活事件和高水平家族情感表达等环境应激源时的复发阈值来发挥作用的。采用前瞻性纵向设计，每月收集23名近期发病的精神分裂症门诊患者的生活事件数据。在一项组间方差分析中发现，与13名未服药患者的相应月份相比，10名服药患者在复发前一个月独立生活事件的发生频率显著更高。这些发现表明，抗精神病药物可能通过提高患者对复发的易感性阈值而产生预防作用。
