Einhorn T A, Wakley G K, Linkhart S, Rush E B, Maloney S, Faierman E, Baylink D J
Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York 10029-6574.
Calcif Tissue Int. 1992 Aug;51(2):127-31. doi: 10.1007/BF00298500.
Clinical studies on the use of sodium fluoride (NaF) in osteoporotic patients have demonstrated increased spinal bone mass without a reduction in vertebral fracture incidence, and a trend towards reduced appendicular bone mass with an increase in peripheral fracture incidence. As previous reports have suggested that NaF becomes incorporated into bone's crystal structure, possibly affecting bone strength, we sought to examine the relationship among bone fluoride content, bone mass, and skeletal fragility. Twenty-one-day-old female Sprague-Dawley rats were treated with four different doses of NaF. The tibiae were subjected to histomorphometric and biochemical analyses, and the femora were tested in torsion for the properties of strength, stiffness, energy storage capacity, and angular deformation. The results showed that over 50% of the skeleton in these rats was turned over in the presence of NaF. The four different doses resulted in a linear increase in bone F concentration and suggested excellent absorption and incorporation of this drug. No changes in histomorphometric indices of bone formation or turnover were found. Despite the large fraction of bone formed during NaF treatment, and the linear increase in bone fluoride content in relation to dose, there were no changes observed in any of the mechanical properties. These results suggest that, even extensive incorporation of fluoride into bone, in the absence of an effect on bone mass or remodeling, does not significantly alter its capacity to withstand mechanical loads.
关于在骨质疏松患者中使用氟化钠（NaF）的临床研究表明，脊柱骨量增加但椎体骨折发生率未降低，且随着外周骨折发生率增加，四肢骨量有减少趋势。正如先前报道所提示的，NaF会融入骨的晶体结构，可能影响骨强度，我们试图研究骨氟含量、骨量和骨骼脆性之间的关系。对21日龄雌性斯普拉格-道利大鼠给予四种不同剂量的NaF。对胫骨进行组织形态计量学和生化分析，对股骨进行扭转试验以检测其强度、刚度、能量储存能力和角变形特性。结果显示，在存在NaF的情况下，这些大鼠超过50%的骨骼发生了更新。四种不同剂量导致骨氟浓度呈线性增加，表明该药物吸收和融入良好。未发现骨形成或更新的组织形态计量学指标有变化。尽管在NaF治疗期间形成的骨比例很大，且骨氟含量随剂量呈线性增加，但未观察到任何力学性能有变化。这些结果表明，即使氟大量融入骨中，在对骨量或重塑无影响的情况下，也不会显著改变其承受机械负荷的能力。
