TOMASHEFSKI J F, SHILLITO F H, BILLINGS C E, ASHE W F
Calif Med. 1964 Nov;101(5):358-62.
Twenty ambulatory patients with severe chronic pulmonary disease and 24 with severe heart disease were exposed in an altitude chamber to a simulated altitude of 8000 feet such as might exist in pressurized aircraft. Eight of the patients in the pulmonary group experienced undersirable reactions related to hypoxia, hypoventilation, inability to hyperventilate and expansion of gases. None of the 24 patients with cardiac disease experienced this same difficulty and all tolerated the procedure well. The ability to tolerate the stress of moderate altitude is related more to ventilatory efficiency and the maintenance of adequate oxygen saturation than to cardiovascular factors. It is recommended that a thorough evaluation of the cardio-pulmonary patient by clinical and physiological tests be made before exposure to altitude. When severe impairment is demonstrated, the subject may still be able to tolerate moderate altitudes if appropriate measures are provided to cope with the altered physiologic conditions.
20名患有严重慢性肺部疾病的门诊患者和24名患有严重心脏病的患者被置于一个模拟8000英尺高度的低压舱中，这种高度可能存在于增压飞机上。肺部疾病组中有8名患者出现了与缺氧、通气不足、无法过度通气以及气体膨胀相关的不良反应。24名心脏病患者中没有一人出现同样的困难，所有人都能很好地耐受该程序。耐受中等海拔压力的能力更多地与通气效率和维持足够的氧饱和度有关，而不是与心血管因素有关。建议在让心肺疾病患者暴露于高海拔之前，通过临床和生理测试对其进行全面评估。当显示出严重损害时，如果采取适当措施来应对生理状况的改变，患者仍可能能够耐受中等海拔。
