兔对静脉注射可溶性及细胞附着性肠道细菌抗原的抗体反应差异。
DIFFERENCES IN ANTIBODY RESPONSE OF RABBIT TO INTRAVENOUSLY INJECTED SOLUBLE AND CELL-ATTACHED ENTEROBACTERIAL ANTIGEN.
作者信息
NETER E, WHANG H Y, SUZUKI T, GORZYNSKI E A
出版信息
Immunology. 1964 Nov;7(6):657-64.
A study was made of the antigenicity of soluble and cell-attached common antigen obtained from enteric bacteria. This antigen becomes readily attached to erythrocytes, which become agglutinable in the presence of the corresponding antibody. Although the common antigen is extractable from numerous species and serogroups of Enterobacteriaceae, in only a few, notably O14, does it engender antibodies in the rabbit upon intravenous injection. It is shown that antibodies against the common antigen are produced after intravenous injection of cell-attached antigen from O111, spp. and spp. but not, or only slightly, after administration of soluble antigen. Antibodies are also formed after injection of antigen attached to C3H mouse fibroblast (L) cells. Intravenous injection of equivalent amounts of common antigen from O14, O111, and results in antibody formation against the common antigen only with that from O14.
对从肠道细菌中获得的可溶性和细胞附着性共同抗原的抗原性进行了研究。这种抗原很容易附着在红细胞上，在相应抗体存在的情况下红细胞会发生凝集。尽管共同抗原可从肠杆菌科的众多菌种和血清群中提取出来，但只有少数几种，特别是O14，在静脉注射到兔子体内时会产生抗体。结果表明，静脉注射来自O111、 spp.和 spp.的细胞附着性抗原后会产生针对共同抗原的抗体，但注射可溶性抗原后则不会产生抗体，或者只会产生少量抗体。注射附着在C3H小鼠成纤维细胞（L）上的抗原后也会形成抗体。静脉注射等量的来自O14、O111和 的共同抗原，只有来自O14的抗原会引发针对共同抗原的抗体形成。
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