Dua H S, Lee R H, Lolley R N, Barrett J A, Abrams M, Forrester J V, Donoso L A
Research Division, Wills Eye Hospital, Philadelphia.
Curr Eye Res. 1992;11 Suppl:107-11. doi: 10.3109/02713689208999519.
Experimental autoimmune uveitis (EAU) and experimental autoimmune pinealitis (EAP) are CD4+ T cell mediated inflammatory diseases of the retina and uveal tract of the eye and the pineal gland respectively. They can be induced in experimental animals by immunization with several well characterized retinal autoantigens. We induced a mild to moderate EAU and EAP in Lewis rats by immunization with phosducin, a 33K retinal phosphoprotein which is involved in the phototransduction of vision. In contrast to the severe EAU induced by other retinal antigens like S-antigen (SAg) or interstitial retinoid binding protein (IRBP), the clinical disease was late in onset, low grade in severity and predominantly affected the posterior segment of the eye. Our study demonstrates that another photoreceptor cell protein, phosducin, is capable of eliciting EAU and EAP.
实验性自身免疫性葡萄膜炎（EAU）和实验性自身免疫性松果体炎（EAP）分别是由CD4 + T细胞介导的眼部视网膜和葡萄膜以及松果体的炎症性疾病。通过用几种特征明确的视网膜自身抗原进行免疫接种，可以在实验动物中诱发这些疾病。我们用视紫红质蛋白免疫Lewis大鼠，诱导出轻度至中度的EAU和EAP，视紫红质蛋白是一种33K的视网膜磷蛋白，参与视觉的光转导。与其他视网膜抗原如S抗原（SAg）或间质类视黄醇结合蛋白（IRBP）诱导的严重EAU不同，临床疾病发病较晚，严重程度较低，主要影响眼的后段。我们的研究表明，另一种光感受器细胞蛋白视紫红质蛋白能够引发EAU和EAP。
