Duguid I G, Boyd A W, Mandel T E
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Curr Eye Res. 1992;11 Suppl:153-9. doi: 10.3109/02713689208999526.
Immunoperoxidase staining of samples of normal human retina and choroid was performed to demonstrate selected adhesion molecules in vivo. Intercellular adhesion molecule-1 (ICAM-1), lymphocyte function-associated antigen-3 (LFA-3) and endothelial leucocyte adhesion molecule-1 (ELAM-1) were expressed on retinal vascular endothelium and ICAM-1 and ELAM-1 in the region of the external limiting membrane. The very late antigen-2 (VLA-2) was found around the retinal ganglion cells and in the inner and outer fibre layers. The endothelium on the choriocapillaris showed moderate staining of ICAM-1, and slight staining of LFA-3 and ELAM-1. The presence of these molecules in this distribution strongly suggests they have an important role in the pathogenesis of immunologically mediated ocular conditions.
对正常人视网膜和脉络膜样本进行免疫过氧化物酶染色，以在体内显示选定的黏附分子。细胞间黏附分子-1（ICAM-1）、淋巴细胞功能相关抗原-3（LFA-3）和内皮白细胞黏附分子-1（ELAM-1）在视网膜血管内皮上表达，且在外界膜区域表达ICAM-1和ELAM-1。极迟抗原-2（VLA-2）在视网膜神经节细胞周围以及内、外纤维层中被发现。脉络膜毛细血管上的内皮显示出ICAM-1的中度染色，以及LFA-3和ELAM-1的轻度染色。这些分子以这种分布形式存在强烈表明它们在免疫介导的眼部疾病发病机制中起重要作用。
