Duguid I G, Boyd A W, Mandel T E
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Aust N Z J Ophthalmol. 1991 Nov;19(4):309-16. doi: 10.1111/j.1442-9071.1991.tb00678.x.
This study examines the expression of some selected adhesion molecules likely to be important in the migration of leucocytes across the blood-retinal and blood-aqueous barriers in samples of normal human retina and choroid by immunoperoxidase staining. ICAM-1, LFA-3 and ELAM-1 were expressed on retinal endothelium and ICAM-1, ELAM-1 and CD44 in the region of the external limiting membrane. VLA-2 was found around the retinal ganglion cells and in the inner and outer fibre layers and is likely to be important in maintaining the structural integrity of the retina. The endothelium on the choriocapillaris showed moderate staining of ICAM-1, and slight staining of LFA-3 and ELAM-1. These molecules may have an important functional role in the pathogenesis of many immunological ocular conditions, including uveoretinitis and corneal allograft rejection.
本研究通过免疫过氧化物酶染色，检测了一些选定的黏附分子在正常人视网膜和脉络膜样本中白细胞穿越血视网膜屏障和血房水屏障迁移过程中可能发挥的重要作用。ICAM-1、LFA-3和ELAM-1在视网膜内皮细胞上表达，而ICAM-1、ELAM-1和CD44在外界膜区域表达。VLA-2在视网膜神经节细胞周围以及内、外纤维层被发现，可能在维持视网膜的结构完整性方面发挥重要作用。脉络膜毛细血管内皮细胞显示出ICAM-1的中度染色，以及LFA-3和ELAM-1的轻度染色。这些分子可能在包括葡萄膜炎和角膜移植排斥反应在内的许多免疫性眼部疾病的发病机制中发挥重要的功能作用。
